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  • Evidence is increasing that all addiction without exception is related to difficulties with the brain's reward center, specially the mesolimbic system. This section of the problem regulates reward responses in acquiring food and sex, along with nurturing infants and children. One of the most important neurotransmitters linked to reward responses, both after they malfunction and whenever they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the quantity of dopamine released in responding to a stimulus"(Bostwick & Bucci, 2008).

    Using two separate drugs to shed pounds can be very effective you can find combinations as you're watching FDA now awaiting approval. When dealing with weight-loss and the those who go through it you need to err on the side of caution and allow FDA do its job and demand some research be done so your public is aware of the side effects and hazards of the medications before we drive them. Keep in mind that drug companies will be in business to earn money and that they would say anything to keep people on their own medications.

    Researchers found out that participants taking this drug to get a year, dropped a few pounds within 4 weeks and have kept the body weight off throughout the 56 weeks of the study. Contrave is a combination with the drugs naltrexone and bupropion, which seems to reflect a new trend of weight-loss drugs that are made up of multiple active ingredient, which might make them more effective and safer.

    Combo-pilling could be the newest fad or in addition to this the newest to come under scrutiny and so it is just more publicly known in recent months, comb-pilling to lose weight has been around since the eighties. The biggest reason that utilizing a combination of pills is now popular may be the fact that since right now there are not any long term prescription weightloss pills that have been authorized by the FDA aside from orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications even though some of the combinations happen to be rejected or have yet to be licensed by the FDA.

    Seizures really are a side effect with Contrave and mustn't be taken in people who have seizure disorders. The drug may also raise hypertension and heart rate, and must not be used in individuals with a history of cardiac arrest or stroke in the last six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy using the drug.

    The FDA also warned that Contrave can raise blood pressure and heart rate and must stop used in patients with uncontrolled high blood pressure levels, along with by anyone with heart-related and cerebrovascular (circulation system dysfunction impacting the mind) disease. Patients using a history of heart attack or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes which has a boxed warning to alert medical professionals and patients on the increased chance of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for stop smoking.

    'The intent of this bill is to give police force and district attorneys an instrument to address illicit drug use among women that are pregnant through treatment programs," Tennessee governor Bill Haslam said.